Thread:Matsczon/@comment-72.9.5.141-20150214235021/@comment-4511886-20150215100143

Sanctuary Guardian is all about punishing the openings he gives you. Smaller, quicker weapons are safer to use, but heavier ones allow you to deal more damage. Quick weapons are safer if you can survive a long time against him, but the stronger weapons are more effective if you can figure out how many attacks each opening allows.

Other than that, don't get greedy. His poison and ability to fly can easily turn the fight into watching your health drain while you can't do anything about it.

I would also recommend trying to max out your BKS to +5. If you killed Seath (the boss in Duke's Archives, the area where the Broken Pendant is) you can warp to his bonfire and farm the clams just outside for Twinkling Titanite.