User blog comment:Brainwasher5/Highest damage possible?/@comment-177.83.196.21-20140417123232

The highest hitting weapon is the Enchanted Great Club +5, it does over 810 damage with maxed out strength and intelligence, in second place we have the Enchanted Demon Great Machete +5 and third is the Enchanted Demon Greataxe +5, both with the same stats.

Worth of note however is that all of these are very slow, so you have to time the attacks perfectly.