Board Thread:Wiki Discussion/@comment-4526779-20160119151217/@comment-4511886-20160119173631

What you essentially want to do is minimise the amount of overkill damage you do. Overkill damage is the damage dealt past what is required. E.g, if you hit an enemy with 100 HP for 125 damage, you've done 25 overkill damage.

S tacking Poison and Toxic effects is usually the easiest way to minimise the damage. This is because both Poison and Toxic always deal 15 damage per tick, which means that you'll be off by 14 HP at most. You can use a weapon to change the total value to be lower, although it's a bit tricky unless you have something that deals a very low, and consistent, amount of damage.